Compound - Cancer - Knowledgebase
|
Leukaemia
|
Lung
|
Breast
|
Ovary
|
Prostate
|
Stomach
|
Colon
|
Pancreas
|
Brain
|
Melanoma
|
Bladder
|
Liver
|
Cervical
|
Anal
|
Gallbladder
|
Oropharynx
|
Larynx
|
Nasopharynx
|
Hypopharynx
|
Oesophagus
|
Vulva
|
Oral
|
Testis
|
Uterine
|
Kidney
|
Tryroid
|
NonHodgkin
|
Hodgkin
|
Myeloma
|
5-Fluorouracil
|
116
|
∞
|
∞
|
125
|
38
|
∞
|
∞
|
∞
|
13
|
55
|
251
|
224
|
120
|
∞
|
111
|
65
|
73
|
97
|
88
|
172
|
58
|
68
|
1
|
3
|
127
|
4
|
0
|
0
|
0
|
Sorafenib
|
∞
|
∞
|
∞
|
207
|
283
|
∞
|
∞
|
168
|
229
|
211
|
35
|
∞
|
162
|
0
|
8
|
0
|
6
|
14
|
2
|
1
|
0
|
78
|
1
|
14
|
∞
|
176
|
30
|
0
|
46
|
Docetaxel
|
1
|
∞
|
∞
|
∞
|
∞
|
∞
|
25
|
104
|
1
|
33
|
55
|
1
|
6
|
9
|
0
|
27
|
19
|
31
|
32
|
20
|
0
|
29
|
2
|
20
|
2
|
11
|
0
|
0
|
0
|
Paclitaxel
|
54
|
∞
|
∞
|
∞
|
∞
|
∞
|
85
|
∞
|
82
|
184
|
142
|
13
|
∞
|
16
|
1
|
14
|
8
|
15
|
9
|
22
|
10
|
5
|
34
|
304
|
5
|
16
|
0
|
0
|
1
|
Gemcitabine
|
∞
|
∞
|
178
|
234
|
26
|
16
|
73
|
∞
|
47
|
25
|
∞
|
15
|
7
|
7
|
124
|
0
|
0
|
3
|
0
|
1
|
0
|
1
|
2
|
0
|
16
|
0
|
12
|
1
|
0
|
Mitomycin-C
|
142
|
∞
|
210
|
66
|
7
|
∞
|
∞
|
111
|
0
|
56
|
∞
|
99
|
57
|
∞
|
19
|
3
|
0
|
1
|
3
|
5
|
16
|
1
|
0
|
2
|
5
|
0
|
1
|
0
|
2
|
Doxorubicin
|
∞
|
∞
|
∞
|
∞
|
200
|
∞
|
256
|
103
|
65
|
212
|
∞
|
∞
|
38
|
9
|
9
|
0
|
0
|
6
|
2
|
5
|
1
|
1
|
46
|
101
|
29
|
68
|
∞
|
∞
|
∞
|
Etoposide
|
∞
|
∞
|
286
|
292
|
118
|
164
|
37
|
8
|
175
|
28
|
57
|
0
|
15
|
1
|
3
|
0
|
0
|
1
|
0
|
2
|
3
|
0
|
∞
|
6
|
6
|
5
|
∞
|
∞
|
191
|
CGP-082996
|
118
|
160
|
∞
|
57
|
88
|
30
|
82
|
64
|
121
|
∞
|
27
|
32
|
16
|
0
|
3
|
1
|
1
|
2
|
1
|
1
|
1
|
21
|
1
|
9
|
10
|
7
|
34
|
2
|
17
|
Rapamycin
|
79
|
145
|
242
|
48
|
51
|
24
|
15
|
50
|
171
|
34
|
6
|
47
|
1
|
0
|
2
|
0
|
0
|
0
|
1
|
0
|
0
|
2
|
0
|
31
|
∞
|
10
|
23
|
1
|
19
|
Erlotinib
|
2
|
∞
|
109
|
26
|
3
|
2
|
77
|
∞
|
41
|
7
|
1
|
5
|
0
|
3
|
2
|
1
|
0
|
1
|
1
|
1
|
1
|
6
|
0
|
1
|
18
|
1
|
0
|
0
|
0
|
Gefitinib
|
8
|
∞
|
256
|
15
|
48
|
7
|
92
|
112
|
48
|
4
|
11
|
10
|
1
|
2
|
1
|
1
|
0
|
3
|
1
|
2
|
3
|
2
|
1
|
3
|
16
|
9
|
0
|
0
|
1
|
Vorinostat
|
58
|
37
|
50
|
8
|
23
|
13
|
18
|
100
|
85
|
3
|
1
|
8
|
4
|
1
|
1
|
1
|
0
|
0
|
0
|
1
|
0
|
3
|
0
|
0
|
1
|
2
|
41
|
1
|
30
|
Camptothecin
|
212
|
∞
|
225
|
∞
|
34
|
∞
|
∞
|
272
|
174
|
27
|
7
|
10
|
63
|
26
|
4
|
0
|
0
|
1
|
0
|
3
|
0
|
0
|
2
|
5
|
3
|
0
|
5
|
1
|
0
|
SN-38
|
5
|
∞
|
90
|
94
|
2
|
∞
|
∞
|
249
|
100
|
1
|
2
|
5
|
24
|
19
|
8
|
0
|
0
|
0
|
1
|
3
|
0
|
0
|
3
|
2
|
1
|
0
|
2
|
1
|
0
|
Irinotecan
|
7
|
∞
|
94
|
119
|
3
|
∞
|
∞
|
∞
|
125
|
2
|
5
|
8
|
38
|
42
|
6
|
0
|
0
|
0
|
0
|
7
|
0
|
0
|
8
|
2
|
1
|
0
|
2
|
1
|
0
|
Tretinoin
|
∞
|
64
|
185
|
3
|
22
|
1
|
0
|
7
|
30
|
248
|
3
|
5
|
9
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
2
|
10
|
2
|
0
|
5
|
95
|
7
|
0
|
10
|
GSK269962A
|
20
|
71
|
∞
|
239
|
6
|
0
|
3
|
2
|
68
|
∞
|
0
|
47
|
2
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
1
|
0
|
1
|
2
|
8
|
0
|
0
|
0
|
0
|
GSK429286A
|
∞
|
57
|
∞
|
221
|
7
|
0
|
1
|
1
|
65
|
∞
|
0
|
44
|
2
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
1
|
7
|
0
|
0
|
0
|
0
|
Olaparib
|
9
|
35
|
∞
|
∞
|
75
|
9
|
9
|
19
|
4
|
3
|
2
|
1
|
7
|
3
|
2
|
2
|
1
|
1
|
1
|
1
|
0
|
1
|
1
|
16
|
1
|
1
|
2
|
0
|
0
|
Vinorelbine
|
14
|
∞
|
∞
|
55
|
136
|
0
|
10
|
2
|
3
|
4
|
19
|
0
|
11
|
2
|
0
|
1
|
1
|
1
|
2
|
3
|
1
|
0
|
3
|
0
|
2
|
0
|
15
|
45
|
6
|
Topotecan
|
54
|
200
|
112
|
∞
|
26
|
0
|
9
|
2
|
24
|
2
|
0
|
0
|
38
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
3
|
0
|
0
|
0
|
0
|
1
|
Tamoxifen
|
0
|
45
|
∞
|
128
|
62
|
0
|
8
|
3
|
9
|
51
|
0
|
12
|
1
|
6
|
0
|
0
|
0
|
0
|
0
|
0
|
13
|
0
|
0
|
∞
|
1
|
18
|
-0
|
0
|
0
|
Vinblastine
|
∞
|
∞
|
∞
|
67
|
68
|
0
|
12
|
0
|
23
|
125
|
∞
|
0
|
7
|
2
|
0
|
0
|
0
|
2
|
1
|
1
|
3
|
0
|
∞
|
0
|
179
|
1
|
∞
|
∞
|
14
|
Methotrexate
|
∞
|
∞
|
∞
|
16
|
0
|
57
|
27
|
0
|
25
|
22
|
∞
|
0
|
0
|
0
|
0
|
0
|
1
|
2
|
1
|
0
|
2
|
5
|
14
|
0
|
0
|
0
|
∞
|
∞
|
8
|
Bleomycin
|
130
|
∞
|
9
|
36
|
1
|
0
|
5
|
0
|
13
|
150
|
67
|
0
|
121
|
14
|
0
|
1
|
21
|
14
|
6
|
7
|
49
|
28
|
∞
|
0
|
2
|
11
|
∞
|
∞
|
2
|
Dabrafenib
|
3
|
46
|
1
|
1
|
0
|
1
|
19
|
2
|
8
|
∞
|
0
|
1
|
0
|
2
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
2
|
35
|
0
|
0
|
1
|
PLX-4720
|
3
|
3
|
1
|
1
|
1
|
0
|
12
|
1
|
13
|
230
|
1
|
1
|
1
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
2
|
39
|
1
|
0
|
1
|
PLX4720
|
3
|
3
|
1
|
1
|
1
|
0
|
12
|
1
|
13
|
230
|
1
|
1
|
1
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
2
|
39
|
1
|
0
|
1
|
Trametinib
|
13
|
69
|
9
|
6
|
1
|
2
|
30
|
36
|
17
|
∞
|
1
|
2
|
0
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
0
|
1
|
3
|
2
|
20
|
0
|
0
|
2
|
AZD6244
|
10
|
81
|
15
|
11
|
1
|
5
|
39
|
12
|
7
|
115
|
1
|
5
|
0
|
0
|
1
|
1
|
1
|
3
|
1
|
1
|
1
|
0
|
1
|
2
|
2
|
37
|
1
|
0
|
4
|
Selumetinib
|
10
|
81
|
15
|
11
|
1
|
5
|
39
|
12
|
7
|
115
|
1
|
5
|
0
|
0
|
1
|
1
|
1
|
3
|
1
|
1
|
1
|
0
|
1
|
2
|
2
|
37
|
1
|
0
|
4
|
Temozolomide
|
7
|
26
|
2
|
0
|
0
|
0
|
3
|
1
|
∞
|
∞
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
Rucaparib
|
1
|
3
|
28
|
142
|
9
|
1
|
2
|
6
|
1
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
1
|
2
|
2
|
3
|
1
|
1
|
1
|
2
|
1
|
1
|
0
|
0
|
0
|
NVP-TAE684
|
0
|
5
|
8
|
2
|
2
|
3
|
0
|
1
|
101
|
0
|
6
|
9
|
6
|
0
|
1
|
1
|
1
|
1
|
1
|
0
|
0
|
0
|
1
|
0
|
28
|
1
|
13
|
3
|
4
|
TAE684
|
0
|
5
|
8
|
2
|
2
|
3
|
0
|
1
|
101
|
0
|
6
|
9
|
6
|
0
|
1
|
1
|
1
|
1
|
1
|
0
|
0
|
0
|
1
|
0
|
28
|
1
|
13
|
3
|
4
|
Cyclopamine
|
2
|
4
|
4
|
7
|
14
|
10
|
3
|
56
|
38
|
1
|
1
|
2
|
0
|
1
|
2
|
1
|
0
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
Thapsigargin
|
19
|
0
|
0
|
0
|
29
|
0
|
0
|
1
|
54
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
8
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
NG-25
|
2
|
0
|
1
|
0
|
0
|
0
|
1
|
0
|
56
|
23
|
0
|
0
|
0
|
1
|
1
|
1
|
0
|
1
|
1
|
3
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
ZSTK474
|
0
|
0
|
19
|
0
|
0
|
13
|
36
|
21
|
0
|
6
|
0
|
3
|
0
|
3
|
9
|
1
|
0
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
12
|
0
|
0
|
0
|
CAY10603
|
6
|
3
|
4
|
6
|
1
|
1
|
3
|
1
|
4
|
2
|
0
|
1
|
2
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
1
|
0
|
3
|
3
|
24
|
PHA-665752
|
1
|
21
|
4
|
5
|
2
|
19
|
4
|
3
|
1
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
3
|
6
|
1
|
0
|
1
|
PD-0325901
|
11
|
16
|
2
|
3
|
2
|
1
|
7
|
8
|
2
|
24
|
1
|
0
|
0
|
1
|
2
|
1
|
1
|
3
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
6
|
0
|
0
|
0
|
PD0325901
|
11
|
16
|
2
|
3
|
2
|
1
|
7
|
8
|
2
|
24
|
1
|
0
|
0
|
1
|
2
|
1
|
1
|
3
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
6
|
0
|
0
|
0
|
Enzastaurin
|
0
|
5
|
1
|
2
|
0
|
3
|
21
|
6
|
3
|
3
|
0
|
4
|
0
|
15
|
3
|
2
|
1
|
1
|
2
|
0
|
0
|
0
|
0
|
0
|
1
|
1
|
3
|
0
|
3
|
XAV939
|
2
|
14
|
2
|
5
|
3
|
10
|
22
|
3
|
5
|
1
|
1
|
5
|
5
|
1
|
1
|
2
|
1
|
2
|
2
|
1
|
1
|
1
|
1
|
7
|
0
|
2
|
1
|
0
|
0
|
Embelin
|
25
|
16
|
19
|
0
|
1
|
0
|
3
|
2
|
0
|
12
|
6
|
2
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
3
|
0
|
0
|
-0
|
0
|
0
|
Seliciclib
|
20
|
5
|
23
|
2
|
5
|
0
|
8
|
2
|
2
|
5
|
4
|
1
|
2
|
2
|
2
|
2
|
0
|
2
|
1
|
1
|
0
|
1
|
0
|
0
|
3
|
0
|
0
|
0
|
7
|
Pictilisib
|
9
|
7
|
44
|
7
|
2
|
1
|
3
|
9
|
5
|
8
|
2
|
1
|
2
|
2
|
1
|
1
|
1
|
2
|
2
|
1
|
1
|
1
|
1
|
4
|
1
|
5
|
4
|
1
|
2
|
AZD0530
|
3
|
35
|
37
|
13
|
12
|
5
|
4
|
5
|
1
|
2
|
2
|
1
|
1
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
6
|
4
|
0
|
0
|
2
|
Saracatinib
|
3
|
35
|
37
|
13
|
12
|
5
|
4
|
5
|
1
|
2
|
2
|
1
|
1
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
6
|
4
|
0
|
0
|
2
|
Luminespib
|
15
|
34
|
26
|
2
|
8
|
5
|
8
|
4
|
0
|
4
|
4
|
1
|
1
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
2
|
1
|
4
|
3
|
1
|
6
|
Motesanib
|
1
|
25
|
3
|
2
|
2
|
1
|
2
|
1
|
1
|
2
|
1
|
1
|
2
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
2
|
1
|
2
|
44
|
1
|
1
|
2
|
TKI258
|
11
|
12
|
16
|
0
|
8
|
5
|
5
|
8
|
1
|
3
|
8
|
2
|
1
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
15
|
49
|
2
|
1
|
0
|
10
|
KU-55933
|
3
|
16
|
45
|
3
|
21
|
1
|
11
|
0
|
6
|
14
|
13
|
3
|
5
|
2
|
1
|
1
|
1
|
1
|
1
|
1
|
6
|
3
|
1
|
5
|
42
|
15
|
26
|
10
|
6
|
Tivozanib
|
1
|
1
|
5
|
2
|
1
|
1
|
7
|
2
|
2
|
1
|
1
|
1
|
1
|
1
|
2
|
2
|
2
|
2
|
2
|
2
|
1
|
1
|
2
|
1
|
145
|
2
|
0
|
1
|
1
|
Temsirolimus
|
12
|
38
|
46
|
11
|
20
|
0
|
7
|
19
|
26
|
15
|
7
|
2
|
1
|
0
|
1
|
1
|
0
|
1
|
1
|
1
|
0
|
0
|
2
|
23
|
∞
|
3
|
65
|
21
|
10
|
Axitinib
|
1
|
51
|
7
|
0
|
7
|
2
|
6
|
16
|
2
|
15
|
1
|
4
|
0
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
0
|
∞
|
55
|
0
|
0
|
0
|
Pazopanib
|
0
|
76
|
15
|
53
|
4
|
1
|
3
|
0
|
0
|
8
|
7
|
1
|
9
|
0
|
1
|
1
|
1
|
1
|
1
|
1
|
0
|
0
|
1
|
5
|
∞
|
44
|
0
|
0
|
2
|
PF2341066
|
2
|
∞
|
15
|
11
|
2
|
9
|
5
|
4
|
3
|
9
|
0
|
7
|
1
|
2
|
1
|
1
|
0
|
1
|
1
|
2
|
1
|
2
|
0
|
1
|
7
|
8
|
35
|
2
|
1
|
Crizotinib
|
2
|
∞
|
15
|
11
|
2
|
9
|
5
|
4
|
3
|
9
|
0
|
7
|
1
|
2
|
1
|
1
|
0
|
1
|
1
|
2
|
1
|
2
|
0
|
1
|
7
|
8
|
35
|
2
|
1
|
Alectinib
|
8
|
∞
|
3
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
2
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
0
|
2
|
5
|
2
|
1
|
1
|
Afatinib
|
0
|
∞
|
53
|
2
|
0
|
5
|
2
|
5
|
1
|
11
|
2
|
2
|
6
|
3
|
3
|
2
|
0
|
2
|
1
|
1
|
0
|
2
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
ZD-6474
|
1
|
124
|
16
|
4
|
5
|
0
|
3
|
1
|
8
|
0
|
0
|
1
|
0
|
1
|
0
|
0
|
1
|
1
|
1
|
0
|
0
|
1
|
0
|
0
|
3
|
279
|
0
|
0
|
1
|
Zibotentan
|
0
|
2
|
3
|
18
|
86
|
2
|
3
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
2
|
2
|
2
|
2
|
3
|
2
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
1
|
1
|
Bicalutamide
|
1
|
14
|
85
|
3
|
∞
|
1
|
13
|
4
|
0
|
8
|
8
|
3
|
1
|
5
|
1
|
1
|
0
|
1
|
1
|
0
|
1
|
0
|
2
|
1
|
3
|
1
|
1
|
1
|
0
|
17-AAG
|
57
|
38
|
82
|
14
|
49
|
3
|
17
|
9
|
10
|
29
|
5
|
4
|
1
|
1
|
2
|
1
|
1
|
1
|
1
|
2
|
0
|
0
|
2
|
0
|
2
|
11
|
2
|
0
|
50
|
Tanespimycin
|
57
|
38
|
82
|
14
|
49
|
3
|
17
|
9
|
10
|
29
|
5
|
4
|
1
|
1
|
2
|
1
|
1
|
1
|
1
|
2
|
0
|
0
|
2
|
0
|
2
|
11
|
2
|
0
|
50
|
Dactolisib
|
23
|
30
|
48
|
13
|
16
|
9
|
32
|
16
|
17
|
13
|
6
|
1
|
2
|
3
|
1
|
1
|
1
|
3
|
4
|
1
|
1
|
1
|
1
|
8
|
11
|
2
|
11
|
3
|
7
|
MG-132
|
67
|
24
|
49
|
6
|
28
|
10
|
22
|
13
|
22
|
10
|
1
|
2
|
3
|
0
|
1
|
0
|
0
|
1
|
2
|
0
|
0
|
1
|
1
|
2
|
1
|
4
|
3
|
0
|
24
|
Doramapimod
|
5
|
18
|
127
|
21
|
22
|
4
|
34
|
23
|
8
|
9
|
1
|
2
|
1
|
0
|
2
|
1
|
1
|
1
|
1
|
1
|
1
|
2
|
2
|
4
|
2
|
0
|
1
|
0
|
3
|
AZD6482
|
5
|
9
|
123
|
9
|
19
|
0
|
30
|
0
|
4
|
1
|
2
|
0
|
7
|
5
|
1
|
1
|
2
|
1
|
2
|
6
|
2
|
2
|
5
|
4
|
1
|
0
|
1
|
2
|
2
|
PD-0332991
|
11
|
20
|
∞
|
10
|
1
|
2
|
3
|
3
|
11
|
16
|
2
|
2
|
3
|
2
|
1
|
1
|
1
|
1
|
2
|
1
|
2
|
1
|
2
|
6
|
1
|
2
|
5
|
1
|
4
|
Palbociclib
|
11
|
20
|
∞
|
10
|
1
|
2
|
3
|
3
|
11
|
16
|
2
|
2
|
3
|
2
|
1
|
1
|
1
|
1
|
2
|
1
|
2
|
1
|
2
|
6
|
1
|
2
|
5
|
1
|
4
|
EpothiloneB
|
0
|
27
|
75
|
52
|
22
|
0
|
4
|
4
|
3
|
2
|
2
|
0
|
1
|
0
|
1
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
1
|
2
|
6
|
0
|
0
|
1
|
1
|
Talazoparib
|
8
|
13
|
62
|
34
|
6
|
1
|
1
|
2
|
1
|
0
|
1
|
1
|
3
|
1
|
2
|
2
|
2
|
2
|
2
|
2
|
1
|
1
|
2
|
4
|
1
|
1
|
1
|
1
|
1
|
Quizartinib
|
61
|
0
|
∞
|
2
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
2
|
0
|
1
|
1
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
Lapatinib
|
2
|
77
|
∞
|
12
|
3
|
63
|
19
|
16
|
5
|
14
|
14
|
0
|
2
|
2
|
2
|
1
|
1
|
2
|
1
|
2
|
1
|
1
|
0
|
7
|
7
|
2
|
0
|
0
|
0
|
Sunitinib
|
17
|
269
|
82
|
12
|
24
|
12
|
32
|
17
|
13
|
53
|
11
|
11
|
0
|
2
|
1
|
1
|
0
|
1
|
1
|
1
|
0
|
1
|
3
|
2
|
∞
|
156
|
0
|
0
|
1
|
Cabozantinib
|
1
|
76
|
7
|
5
|
90
|
3
|
3
|
6
|
4
|
2
|
7
|
10
|
0
|
0
|
1
|
1
|
1
|
3
|
1
|
1
|
1
|
1
|
2
|
0
|
∞
|
266
|
0
|
0
|
1
|
MK-2206
|
0
|
6
|
9
|
3
|
∞
|
1
|
1
|
1
|
2
|
1
|
∞
|
1
|
0
|
0
|
0
|
0
|
1
|
1
|
1
|
0
|
1
|
0
|
55
|
2
|
∞
|
1
|
0
|
0
|
0
|
Nutlin-3
|
75
|
14
|
20
|
11
|
5
|
0
|
10
|
3
|
3
|
18
|
0
|
4
|
0
|
2
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
0
|
3
|
0
|
3
|
0
|
11
|
1
|
9
|
Tozasertib
|
55
|
3
|
6
|
9
|
2
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
2
|
1
|
2
|
2
|
3
|
2
|
2
|
2
|
1
|
2
|
1
|
2
|
2
|
5
|
1
|
1
|
7
|
Parthenolide
|
57
|
10
|
23
|
1
|
10
|
2
|
9
|
11
|
2
|
6
|
2
|
3
|
2
|
0
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
2
|
1
|
0
|
1
|
0
|
1
|
0
|
5
|
JQ1
|
54
|
13
|
15
|
11
|
18
|
3
|
4
|
9
|
7
|
3
|
2
|
4
|
1
|
0
|
1
|
1
|
1
|
1
|
2
|
1
|
1
|
2
|
1
|
3
|
3
|
5
|
16
|
4
|
18
|
FMK
|
201
|
4
|
3
|
2
|
5
|
6
|
0
|
14
|
23
|
3
|
0
|
2
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
3
|
0
|
0
|
0
|
0
|
0
|
0
|
4
|
ObatoclaxMesylate
|
110
|
15
|
10
|
3
|
1
|
0
|
3
|
5
|
3
|
7
|
2
|
2
|
1
|
1
|
2
|
2
|
1
|
4
|
2
|
2
|
1
|
4
|
1
|
1
|
1
|
4
|
14
|
3
|
8
|
Bryostatin1
|
157
|
8
|
6
|
2
|
2
|
1
|
1
|
4
|
4
|
16
|
0
|
0
|
1
|
1
|
1
|
1
|
1
|
3
|
1
|
1
|
1
|
1
|
1
|
0
|
4
|
0
|
18
|
5
|
2
|
CMK
|
84
|
0
|
0
|
1
|
0
|
0
|
0
|
2
|
2
|
0
|
0
|
1
|
2
|
2
|
1
|
1
|
2
|
1
|
1
|
1
|
1
|
1
|
1
|
0
|
1
|
0
|
1
|
0
|
1
|
Navitoclax
|
84
|
7
|
1
|
2
|
0
|
0
|
0
|
3
|
2
|
1
|
0
|
1
|
0
|
0
|
1
|
1
|
0
|
1
|
1
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
8
|
3
|
3
|
Ruxolitinib
|
314
|
1
|
1
|
5
|
0
|
0
|
0
|
12
|
1
|
1
|
0
|
1
|
0
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
0
|
1
|
0
|
0
|
0
|
5
|
3
|
2
|
Nilotinib
|
∞
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
6
|
0
|
1
|
0
|
1
|
1
|
1
|
0
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
3
|
GW843682X
|
∞
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
4
|
1
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
GNF-2
|
219
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
2
|
1
|
1
|
1
|
2
|
2
|
1
|
1
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
SNX-2112
|
125
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
0
|
0
|
0
|
0
|
1
|
1
|
0
|
1
|
1
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
Midostaurin
|
∞
|
8
|
2
|
1
|
0
|
1
|
1
|
1
|
5
|
4
|
1
|
0
|
0
|
1
|
1
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
1
|
1
|
2
|
0
|
1
|
0
|
4
|
Lestaurtinib
|
112
|
2
|
2
|
2
|
14
|
1
|
1
|
3
|
1
|
0
|
0
|
1
|
2
|
1
|
2
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
2
|
3
|
3
|
2
|
2
|
Bosutinib
|
∞
|
6
|
11
|
0
|
2
|
0
|
1
|
3
|
0
|
0
|
0
|
2
|
1
|
4
|
1
|
1
|
1
|
1
|
2
|
1
|
1
|
2
|
1
|
1
|
0
|
7
|
1
|
0
|
4
|
Ponatinib
|
∞
|
21
|
2
|
1
|
0
|
1
|
1
|
1
|
2
|
1
|
2
|
1
|
0
|
1
|
1
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
1
|
5
|
1
|
8
|
0
|
0
|
2
|
Dasatinib
|
∞
|
47
|
36
|
6
|
29
|
1
|
3
|
15
|
21
|
13
|
0
|
3
|
0
|
49
|
0
|
1
|
1
|
1
|
1
|
0
|
0
|
3
|
0
|
1
|
6
|
5
|
5
|
1
|
7
|
Imatinib
|
∞
|
15
|
2
|
1
|
1
|
0
|
16
|
1
|
2
|
46
|
0
|
0
|
46
|
34
|
0
|
3
|
0
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
26
|
1
|
1
|
0
|
9
|
Veliparib
|
176
|
28
|
11
|
34
|
0
|
5
|
4
|
5
|
0
|
14
|
0
|
1
|
2
|
0
|
0
|
0
|
2
|
1
|
0
|
1
|
0
|
0
|
0
|
0
|
12
|
0
|
77
|
33
|
4
|
Idelalisib
|
∞
|
0
|
0
|
0
|
1
|
0
|
1
|
1
|
1
|
1
|
0
|
0
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
1
|
0
|
0
|
0
|
147
|
74
|
9
|
Belinostat
|
12
|
9
|
3
|
10
|
9
|
2
|
6
|
8
|
1
|
2
|
1
|
3
|
0
|
3
|
1
|
2
|
1
|
2
|
2
|
2
|
1
|
1
|
1
|
1
|
3
|
7
|
48
|
11
|
10
|
Bexarotene
|
14
|
38
|
21
|
1
|
0
|
0
|
1
|
0
|
0
|
3
|
1
|
2
|
0
|
0
|
1
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
1
|
0
|
2
|
22
|
∞
|
8
|
0
|
Cytarabine
|
∞
|
15
|
4
|
7
|
0
|
2
|
0
|
2
|
24
|
11
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
∞
|
∞
|
64
|
Lenalidomide
|
∞
|
0
|
0
|
0
|
6
|
0
|
0
|
2
|
0
|
1
|
0
|
0
|
0
|
0
|
0
|
0
|
0
|
1
|
1
|
0
|
0
|
1
|
1
|
0
|
2
|
1
|
∞
|
136
|
∞
|
Bortezomib
|
∞
|
46
|
22
|
14
|
23
|
0
|
5
|
30
|
9
|
21
|
0
|
1
|
1
|
1
|
1
|
0
|
0
|
0
|
1
|
0
|
0
|
2
|
0
|
0
|
6
|
3
|
∞
|
126
|
∞
|
Panobinostat
|
87
|
13
|
17
|
7
|
12
|
0
|
4
|
9
|
16
|
6
|
2
|
4
|
2
|
1
|
2
|
1
|
1
|
1
|
1
|
2
|
1
|
1
|
1
|
4
|
4
|
7
|
48
|
27
|
∞
|
Compound: |
Cancer: |
P-value: |
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